Explorando Longo Período de Interação entre Sistema Imunológico e HIV
DOI:
https://doi.org/10.5540/tema.2010.011.02.0159Abstract
O Vírus da Imunodeficiência Humana (HIV), infectando células TCD4 +, consegue comprometer gravemente o funcionamento do Sistema Imunológico, resultando em AIDS. Formulamos e analisamos três modelos matemáticos para este processo de infecção. Foi possível encontrar um limiar para a permanência do vírus na corrente sanguínea e evidenciar a necessidade da apoptose de células ativadas, após a eliminação do antígeno. Através da introdução de um termo de exaustão cumulativa (resultado da constante tentativa do sistema imunológico responder à infecção pelo HIV) também reproduzimos a diminuição do número de células T-CD4+ ao longo dos anos.References
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